The condition is also sometimes known as paralysis agitans or shaking palsy. The Parkinson’s Foundation estimates that 60,000 Americans are diagnosed with Parkinson’s every year. But the true number of people who develop the disease may be much higher. (1)
History of Parkinson’s Disease
Symptoms and possible treatments for Parkinson’s were discussed in texts related to Ayurveda, an ancient Indian medical practice that’s been around since as early as 5,000 B.C. (2) A Parkinson’s-like condition was also mentioned in the first Chinese medical text, the Huangdi Neijing, more than 2,500 years ago. Parkinson’s disease was formally recognized in an 1817 paper, “An Essay on the Shaking Palsy,” by James Parkinson, a London apothecary-surgeon and member of the Royal College of Surgeons. (3) Parkinson (1755–1824) observed what are now known as the classic symptoms of Parkinson’s disease, including tremors, rigidity, and postural instability. He theorized that the disease developed because of a problem in the brain’s medulla region. Parkinson’s essay received little attention until 1861, when French neurologist Jean-Martin Charcot and his colleagues distinguished the disease from other neurological conditions and termed it “Parkinson’s disease.” (3) No quick or easy diagnostic tests exist for Parkinson’s disease, so a patient may receive an initial diagnosis of parkinsonism without a more specific condition being confirmed. Classic Parkinson’s disease — referred to as idiopathic because it has no known cause — is the most common and most treatable parkinsonism. About 15 percent of people with parkinsonism have atypical variants, which are also known as Parkinson’s-plus syndromes. (5) Learn More About Parkinsonism
Cognitive issues like dementiaPsychosis, or thoughts and beliefs that aren’t rooted in realityMood disorders such as depression and anxiety, or feelings of apathySleep disorders like insomnia
The primary symptoms of Parkinson’s disease — tremors, muscle stiffness, slow movement, and impaired balance — can vary from person to person depending on what subtype of Parkinson’s they have, but they generally get worse over time. According to a research article published in the journal Movement Disorders, the three Parkinson’s subtypes are:
Akinetic-rigid The predominant symptoms are stiffness, slowed movement, balance issues, and gait difficulties.Tremor-dominant The predominant symptoms are tremors.Mixed Predominant symptoms are a combination of the above two subtypes.
Parkinson’s symptoms often begin on one side of the body and gradually affect both sides of the body, but they tend to be worse on the side they affected first. Learn More About Signs and Symptoms of Parkinson’s Disease
Stages of Parkinson’s Disease
Neurologists usually describe the progression of Parkinson’s symptoms in stages, using the system known as the Hoehn and Yahr scale. (6) These stages are:
Stage 1 Symptoms are seen on one side of the body only.Stage 2 Symptoms are seen on both sides of the body. There’s no impairment of balance.Stage 3 Balance impairment has begun. In this mild-to-moderate stage of the disease, the person is still physically independent.Stage 4 This stage is marked by severe disability, but the person is still able to walk or stand unassisted.Stage 5 The person requires a wheelchair or is bedridden unless assisted.
It’s widely believed that a person with Parkinson’s may be genetically vulnerable to the disease, and that one or more unknown factors in the environment eventually triggers it. Most of the symptoms of Parkinson’s disease come from the loss of neurons in an area of the brain called the substantia nigra. (7) Normally, the neurons in this part of the brain make the chemical messenger (neurotransmitter) dopamine, which allows communication with another area of the brain, the corpus striatum. This communication helps produce smooth, purposeful movement. When the neurons in the substantia nigra die, the resulting loss of communication leads to the motor (movement-related) symptoms of Parkinson’s. (8) Although the cause of this cell death is unknown, many researchers believe that the cells are killed by clumped proteins called Lewy bodies. (8)
What Are Lewy Bodies?
The affected neurons of people with Parkinson’s disease have been found to contain clumped proteins called Lewy bodies. (9) Researchers aren’t yet sure why Lewy bodies form or what role they play in the disease, but Lewy bodies are believed to be toxic. (9) Lewy bodies are clumps of a protein called alpha-synuclein (⍺-synuclein). Neurons can’t break down these protein clumps, which may lead to the death of these cells. (9) Some other theoretical causes of brain cell death in people with Parkinson’s disease include free-radical damage, inflammation, or toxins. Learn More About Lewy Body Dementia
What Are the Risk Factors for Parkinson’s Disease?
Risk factors for Parkinson’s disease include: Genetics People with a first-degree relative (parent or sibling) with Parkinson’s are at an increased risk for the disease — possibly as much as 9 percent greater. Fifteen percent of people with Parkinson’s have a known relative with the disease, but a condition called familial Parkinson’s, which has a known genetic link, is relatively rare. (10) Age The average age of onset is 60 years, and the incidence rises with advancing age. About 4 percent of people have “early-onset” or “young-onset” disease, which begins before age 50. (11) Gender Parkinson’s affects about 50 percent more men than women, for unknown reasons. (12) Pesticide Exposure Exposure to some pesticides has been shown to raise the risk of developing Parkinson’s. Problematic chemicals include organochlorine pesticides like DDT, dieldrin, and chlordane. Rotenone and permethrin have also been implicated. (13) Fungicide and Herbicide Exposure Exposure to the fungicide maneb or the herbicides 2,4-dichlorophenoxyacetic acid (2,4-D), paraquat, or Agent Orange may raise the risk of Parkinson’s. The U.S. Veterans Health Administration considers Parkinson’s to be a possible service-related illness if the person was exposed to significant amounts of Agent Orange. (14) Head Injuries Head injuries may contribute to the development of Parkinson’s in some people. (15) Coffee and Smoking People who drink coffee or smoke tobacco have been found to have a lower risk of Parkinson’s disease, for reasons that remain unclear. (16) Doctors typically make a diagnosis based on the following:
Medical historyA neurological examBlood and lab tests (to rule out other disorders)Brain scans (to rule out other disorders)
Sometimes, people who have a known inherited form of Parkinson’s disease can take a gene test to determine their risk for developing the disease. (17,18)
Prognosis of Parkinson’s Disease
As Parkinson’s progresses, symptoms often worsen. Some people who respond well to therapy have minimal disability issues. Others, however, become severely incapacitated. Although Parkinson’s isn’t considered a fatal disease itself, it can cause life-threatening complications that may shorten your life span. Today, most people living with Parkinson’s disease have close to a normal life expectancy. (19) By the 1940s and 1950s, neurosurgeons had begun to perform surgery on the basal ganglia of the brain, which resulted in improvements in Parkinson’s disease symptoms. While this surgery was sometimes effective, it was also risky — about 10 percent of patients died as a result of the operation. (3) The biggest advance in Parkinson’s treatment came in the 1960s. Researchers identified differences in the brains of people with Parkinson’s associated with low levels of the chemical dopamine, which plays a role in coordinated movement. (3) There’s no cure for Parkinson’s, but a number of treatments can help manage the disease’s symptoms. (17)
Medication Options
Medications for Parkinson’s disease fall into three general categories:
Medications that increase the level of the neurotransmitter dopamine in your brainMedications that affect other neurotransmitters, to help control motor symptomsMedications to help control nonmotor symptoms
Treating Parkinson’s disease with medication can be a balancing act between managing the disease and managing drug side effects. Learn More About Medications for Parkinson’s Disease
Surgical Options
Deep brain stimulation surgery is an option for people with Parkinson’s disease who no longer respond to medications. With this method, doctors implant electrodes in specific areas of the brain. The electrodes connect to a generator that’s implanted in the patient’s chest. The generator sends electrical pulses to the brain, which help reduce symptoms. (17,18)
Alternative and Complementary Therapies
Some people with Parkinson’s disease use complementary therapies to manage their symptoms. These approaches may include:
Exercise Staying physically active can improve flexibility, strength, and mobility.Diet A healthy diet can promote overall health for people with Parkinson’s disease.Massage A massage may help lessen muscle tension and make you more relaxed.Tai chi This ancient type of Chinese exercise can improve balance, strength, and flexibility.Yoga Yoga involves stretching and poses that can help with flexibility and balance.Meditation Some people report that meditation can reduce pain and stress.Feldenkrais method These movement lessons have been shown to reduce depression and improve quality of life. (26)Alexander technique This method focuses on muscle posture and balance. (17,18)Boxing Instructors at the nonprofit organization Rock Steady Boxing teach boxing exercises to help improve agility, muscular endurance, and hand-eye coordination among people with Parkinson’s. Find a class in your area.
Learn More About What to Eat if You Have Parkinson’s Disease
Prevention of Parkinson’s Disease
Researchers don’t know of any proven ways to prevent Parkinson’s disease, but avoiding certain risk factors and adopting a healthy lifestyle may reduce your risk. Some studies have shown a diet high in antioxidants along with regular exercise may play a role in preventing Parkinson’s. Other findings have suggested that compounds like caffeine, niacin, and nicotine may have a protective effect against Parkinson’s disease. (21) Researchers have studied various formulations of nicotine — including intranasal, transdermal, and chewing gum — to see whether they could help with Parkinson’s symptoms, but so far none has been found effective at slowing the progression of Parkinson’s. About 4 percent of people with Parkinson’s are diagnosed before age 50. (1) Men are 1.5 times more likely to develop the disease than women. (1) African Americans remain underrepresented in Parkinson’s-related research studies, which may contribute to the discrepancies in these estimates. (22) Black patients may also be less likely to receive proper care for the disease, research shows. (23, 24) A study published in April 2021 in Parkinsonism and Related Disorders showed that Black people with Parkinson’s were, on average, four years older at the time they received their diagnosis than white people with this condition. (23) The study also revealed racial disparities when it comes to diagnosis, treatment, survival, and medication use that negatively impact Black people compared with white people who have Parkinson’s. (23) For example, Black people were more likely to receive care for Parkinson’s through the emergency department than white people, and were less likely to be taking medications for parkinsonism and mood disorders than white people. (23) These disparities likely result from factors such as health insurance status and access to medical care, among others, according to a study published in August 2021 in the Journal of Cross-Cultural Gerontology. (24)
Essential tremorNormal pressure hydrocephalusDementia with Lewy bodies Multiple system atrophy (MSA)Progressive supranuclear palsy (PSP)Corticobasal degeneration (CBD) (18,24)
This organization funds patient services, educational efforts, and research related to Parkinson’s disease. Check out their resources for veterans with Parkinson’s, early-onset Parkinson’s, and caregivers. Interested in getting involved? Find your local chapter. Davis Phinney Foundation for Parkinson’s Geared toward helping people with Parkinson’s disease live well, this foundation educates patients and caregivers about wellness through its Live Well TODAY webinar series and its Every Victory Counts manual. European Parkinson’s Disease Association (EPDA) The leading Parkinson’s organization in Europe, this association offers free resources on home-based workouts for people with Parkinson’s, how to create a “Parkinson’s Passport” for use while traveling, and more. The Michael J. Fox Foundation for Parkinson’s Research This foundation was founded in 2000 by the actor Michael J. Fox, who received a diagnosis of young-onset Parkinson’s disease in 1991. Take a look at Parkinson’s 360, the foundation’s guide for living with Parkinson’s. Or if you’d like to join a Parkinson’s research study, visit the Fox Trial Finder. Parkinson’s Foundation With a mission to empower people with Parkinson’s, this foundation funds research geared toward improving care and treatment for the disease. Sign up for their newsletter to receive news updates and information about Parkinson’s resources. Or if you need help connecting with a health professional, call the foundation’s helpline at 800-4PD-INFO (800-473-4636). Learn More About Additional Resources and Support for Parkinson’s Disease
